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Resumen Si bien aún no hay una definición precisa de inflamación sistémica en EPOC, su reconocimiento se ha basado en estudios que han demostrado un aumento de concentración plasmática de diversos marcadores inflamatorios entre ellos proteína C reactiva (PCR) y, en los últimos años se ha postulado también la microalbuminuria. Los objetivos de este trabajo fueron determinar la microalbuminuria y la PCR como potenciales biomarcadores de inflamación sistémica. Para ello se reclutaron pacientes EPOC estable y tabaquistas no EPOC diagnosticados mediante espirometria, mayores a 40 años sin HTA ni diabetes tipo I ó II, en el periodo comprendido entre octubre de 2017 a marzo de 2019. A ambos grupos se le extrajo una muestra de sangre venosa para determinar PCR ultrasensible y 3 muestras de orina para determinar microalbuminuria, tomando una media de las mismas. Se consideró albuminuria significativa cuando en al menos dos de tres determinaciones hubiese valores entre 30 y 300 mg/g de creatinina urinaria. La PCR ultrasensible se consideró positiva con un valor igual o superior a 5 mg/L. De los 47 pacientes analizados se obtuvo una albuminuria media de 13.91 ± 5.04 en el grupo EPOC en comparación con 2.50 ± 0.36 del grupo control. De la misma forma se compararon las medias de PCR ultrasensible, arrojando un valor de 5.06 ± 2.24 en los pacientes EPOC en relación a 2.46 ± 0.51 de los controles. Ambas variables mostraron diferencias estadísticamente no significativas entre los grupos de estudio (p = 0,058 para albuminuria media y p = 0.330 para PCR ultrasensible).
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Abstract There isn't yet a clear definition for systemic inflammation in COPD (chronic obstructive pulmonary disease), but its recognition has been based on studies that show an increase in the plasma concentration of various inflammatory markers, such as the c-reactive protein (CRP), and in recent years, also the microalbuminuria has been suggested. The purposes of this work were to determine the microalbuminuria and CRP as potential biomarkers of systemic inflammation. We enrolled patients with stable COPD and non-COPD smokers diagnosed through spirometry; older than 40 years without AHT (arterial hypertension) or diabetes type I or II, between October 2017 and March 2019. In both groups, a venous blood sample was collected to determine high-sensitivity CRP and 3 urine samples were taken to determine microalbuminuria, calculating the mean value. At least two out of three determinations between 30 and 300 mg/g of urine creatinine were considered to be significant albuminuria. The high-sensitivity CRP was considered positive with a value ≥ 5 mg/L. Of the 47 analyzed patients, a mean albuminuria of 13.91 ± 5.04 was obtained in the COPD group, in comparison with 2.50 ± 0.36 in the control group. Also, the high-sensitivity CRP mean values were compared, showing 5.06 ± 2.24 in COPD patients and 2.46 ± 0.51 in the control group. Both variables showed non-statistically significant differences between the study groups (p = 0.058 for mean albuminuria and p = 0.330 for high-sensitivity CRP).
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Introducción: En la actualidad, la tuberculosis es la novena causa de muerte y la primera por enfermedades infecciosas. Según estimaciones hay 10 millones de nuevos casos de enfermos por año en todo el mundo con más de un millón de muertes anuales. El objetivo del presente trabajo es caracterizar los pacientes diagnosticados de tuberculosis y tratados en el Hospital Transito Cáceres de Allende de la Ciudad de Córdoba. Material y métodos: Se realizó un estudio retrospectivo, observacional, descriptivo, de corte transversal. Resultados: Se incluyeron 69 pacientes, 57,9% fueron hombres. El grupo etario más afectado fue entre los 26 y 65 años. El 35% no tenía trabajo, y de los que si tenían, una gran parte no tenía estabilidad laboral. Ocho pacientes tenían algún grado de inmunocompromiso, presentando solo 1 infección por HIV. No hubo casos de pacientes con resistencia a drogas antituberculosas. Conclusiones: Las características epidemiológicas de nuestros pacientes son similares a otras publicaciones de la región. Conocerlas nos permite tomar decisiones de manejo diario, tanto en diagnóstico y tratamiento, como en la prevención y control de foco para limitar la propagación de la misma.
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Humanos , Masculino , Tuberculose , Saúde Pública , EpidemiologiaRESUMO
Introduction: At present, tuberculosis is the ninth cause of death, the first from infectious diseases. According to some estimates, there are 10 million new cases of ill people with tuberculosis per year throughout the world, with more than one million annual deaths. The objective of this study was to characterize patients diagnosed with tuberculosis who were treated in the Hospital Transito Cáceres de Allende of the city of Córdoba. Materials and Methods: We conducted a retrospective, observational, descriptive, cross-sectional study. Results: 57.9% of the 69 patients included in the study were male. The most affected age group was between 26 and 65 years. 35% did not have a job, and a large part of those who were employed did not have job stability. Eight patients were partially immunocompromised and there was only 1 case of HIV infection. There were no cases of antituberculous drug-resistant patients. Conclusions: The epidemiological characteristics of our patients are similar to other publications of the area. Knowing about them allows us to make decisions regarding daily management, both in terms of diagnosis and treatment, and also prevention and outbreakcontrol, in order to limit disease propagation.
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Humanos , Masculino , Tuberculose , Saúde Pública , EpidemiologiaRESUMO
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Humanos , Feminino , Pessoa de Meia-Idade , Amiloidose/etiologia , Pneumopatias/etiologia , Mieloma Múltiplo/complicações , Alvéolos Pulmonares/patologia , Calcinose/complicações , Amiloidose/diagnóstico , Pneumopatias/diagnóstico , Mieloma Múltiplo/diagnóstico , Biópsia , Pulmão/diagnóstico por imagem , Toracoscopia , Metaplasia/diagnóstico por imagemRESUMO
Objetivos: Determinar las características epidemiológicas de los pacientes con diagnóstico de Tuberculosis (TB) que asistieron en el período comprendido entre el 01 de mayo de 2010 y 30 de abril de 2013 al Hospital Tránsito Cáceres de Allende (HTCA) de Córdoba Argentina. Materiales y métodos: Estudio descriptivo, observacional y prospectivo, en 106 pacientes mayores de 15 años. Resultados: Se observó mayor frecuencia entre los 15 -35 años (48%), 55% fueron masculinos, 90% fueron argentinos, la mortalidad fue del 4%; el 50% con ocupación estable, comorbilidades: Diabetes mellitus 19% y VIH 1%, tabaquismo 61%, alcohol 23% y drogas ilícitas 22%, IMC
Objectives: To determine the epidemiologic characteristics of patients diagnosed with TB who attended the hospital Transito Caceres de Allende of Cordoba, Argentina in the period from May 1st, 2010 to April 30th, 2013. Materials and methods: Descriptive, observational and prospective study in 106 patients older than 15 years old. Results: There was a higher frequency on the 15 to 35 years old (48%), male 55%, Argentine 90%, case fatality 4%, stable employment 50%, comorbidities: diabetes mellitus 19% , HIV 1%, tobacco smoking 61%, alcohol addiction 23%, consumption of illegal drugs 22%, BMI lower than 21: 63%. Bacteriologic diagnosis: positive direct smear microscopy 73%, positive culture 66% and pathologic histology 20%, treatment adherence: adherence 97%, healed 92 %, self administered treatment 96%, MDR-TB 3%. Forms of presentations: pulmonary TB 72%, extrapulmonary TB 28%. Radiological abnormalities: unilateral infiltrates with cavity 27%, unilateral without cavity 20%. Laboratory tests: Leukocytosis 15%, high erythrocyte sedimentation 82%, Adverse Drug Reactions: hepatoxicity 4%. Conclusions: Male young adult is more likely to become ill. Diabetes, HIV and BMI < 21 must prompt screening studies in symptomatic patients. Smoking habit, unemployment and bad social economics conditions are positive epidemiologic factors. Usual laboratory data is nonspecific but can provide some guiding. Thorax (chest) radiography, microscopy and culture are accessible diagnostic resources. MDR-TB is not yet a relevant problem in our hospital. Treatment related hepatotoxicity did not require interruption of therapy. Self administered treatment strategy with high adherence, low dropout and high healing rate indicate a big success of the program.
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Tuberculose , EpidemiologiaRESUMO
La remodelación de la via aérea correspondie a cambios estructurales del tracto respitatorio que se produce en distintas enfermedades respitarorias siendo el asma una de las mas impotantes.
